World Journal of Peri and Neonatology <p><strong>World Journal of Peri &amp; Neonatology (WJPN)</strong> is a peer-reviewed and free-access journal founded in 2017, by Mother and Newborn Health Care Center, Yazd, Iran. The Journal publishes articles in English across on all aspects of preconceptional, perinatal, and postpartum periods; and of fetuses and newborn infants during and beyond their initial hospital stay. The Editorial Board is comprised of an Editor-in-Chief and Associate Editors, highly qualified scientists of different institutions across Iran or overseas.The WJPN audience includes specialist in obstetrics, neonatology, perinatology, maternal/fetal medicine, and neonatal and perinatal nurses. It publishes peer-reviewed clinical research articles, review or update articles, case reports, commentaries,editorials and letters to the Editor. However, other types of articles may be included depending on the interest of the Journal or the need to&nbsp;publish relevant subject matters not suitable for the categories above.</p> en-US (Dr Mahta Mazaheri MD, PhD) (Arman Research Institute) Sat, 18 Nov 2017 00:00:00 +0330 OJS 60 Prevalence of Congenital Anomalies in Newborns in Zabol: a Single Hospital Based Study <p><strong>Background:</strong> Congenital anomalies are conditions of prenatal origin that are present at birth, potentially impacting an infant's health, development and survival. The birth of a newborn with congenital anomalies imposes financial and emotional burdens on families. The aim of this study was to investigate the epidemiology of congenital anomalies in 2014 in Zabol, Iran</p> <p><strong>Methods:</strong> This cross-sectional study was carried out in the Amir-Al-Momenin Hospital between May of 2013 and April 2014. All the live born babies born were included, and we have examined all newborns for the presence of congenital anomalies.</p> <p><strong>Results: </strong>During the twelve months, 9,309 babies were born, of which 72 newborns were affected with a congenital malformations, making the prevalence 7.73%. The congenital anomalies affected significantly higher proportion of male newborns (66.7%) than female newborns (33.3%). Of them, musculoskeletal system abnormalities account for 45.9% of the total abnormalities allocating the highest frequency to itself. Subsequently, central nervous system abnormality (19.4%), gastrointestinal anomaly (15.3%), urinary tract abnormality (9.7%), chromosomal abnormality (2.8%), and multiple anomalies (1.4%) were frequent, respectively.</p> <p><strong>Conclusion:</strong> The relatively high prevalence of congenital anomalies in the studied population in comparison with other studies in Iran suggests the necessity of prenatal genetic counseling as the most important inhibitory factor in the occurrence of congenital abnormalities. In addition, planning for education, increasing the awareness about the congenital abnormalities risk factors, avoiding the arbitrary use of herbal and synthetic drugs during pregnancy, preventing interfamily marriages/consanguineous marriage, and increasing the awareness of families about the complications induced by interfamily marriage/consanguineous marriage are recommended.</p> <p><strong>Keywords:</strong> Congenital anomaly, Chromosomal abnormality, Prenatal, Counseling</p> Mojtaba Jahantiq, Mahta Mazaheri, Tayebeh Rabaninia, Hossein Neamatzadeh, Nooshin Amjadi ##submission.copyrightStatement## Mon, 02 Jul 2018 12:43:15 +0430 A Survey on the Relationship between Ages above 35 Years and Gestational Diabetes Mellitus <p><strong>Background:</strong> The aim of this study was to determine the relationship between ages above 35 years old and gestational diabetes mellitus in Zabol.</p> <p><strong>Methods:</strong> This study was conducted in Zabol city during 2016-2017. Analyzing the data to check the validity of the hypothesis in any type of research is of particular importance and is performed nowadays in most research studies based on the data gathered from the subjects under study. Data analysis is one of the main and most important parts of any research. Raw data is analyzed using statistical software.</p> <p><strong>Results: </strong>The results of this study showed that according to the gestational diabetes mellitus score of 150 mothers, about gestational diabetes, 11 cases (7.3%) had gestational diabetes, and 132 (92.7%) others have not experienced gestational diabetes. Generally, according to the average score (1.92), there is no gestational diabetes in mothers.</p> <p><strong>Conclusion:</strong> The most important risk factors for gestational diabetes are age-obesity and familial history, respectively.</p> <p><strong>Keywords</strong>: Gestational diabetes, High-age, Zabol city</p> Ashrafali Rezaie Kehkhaie, Kolsoum Rezaie Kahkhaie, Leili Rezaie Kahkhaie, Maryam Koochakzai, Khadijeh Rezaie Keikhaie ##submission.copyrightStatement## Mon, 02 Jul 2018 12:47:48 +0430 Isolation of Beta-Lactamase Producing Genes (SHV, CTX-M1, CTX-M2, CTX-M3) in Escherichia coli Isolated from Pregnant Woman Patients <p><strong>Background:</strong> In recent decades, extended spectrum beta-lactamase (ESBL) generating bacteria have increased universally. Among the most important causative agents of nosocomial infections throughout the world, <em>Escherichia coli </em>as main ESBL-producing bacteria are so highly regarded. Trends in the treatment of infections by such bacteria have led to a global concern.</p> <p><strong>Methods:</strong> All strains were cultured and identified by the Clinical Microbiology Laboratory and were recovered from blood and urine cultures. <em>In-vitro</em> presence of ESBL was confirmed with Clinical and Laboratory Standard Institute double disc and PCR for CTX-M1, CTM-M2, CTX-M3 method.</p> <p><strong>Results: </strong>The results of this study showed that Escherichia coli samples were resistant to AN (42.85%), GM (28.57%), AM (35.71%), AMC (35.71%), CZ (35.71%), and AZM (50%) antibiotics. While the most susceptible to antibiotic was ampicillin (64.28%), the least resistance to antibiotics was gentamicin.</p> <p><strong>Conclusion:</strong> The current situation of multiple bacterial antibiotic resistance has become a worrisome issue in UTI. Multi-drug-resistant <em>E. coli</em> can be readily encountered in hospital settings during daily clinical practice, and urologist should act timely. The management of such infections is extremely important for the future, with particular reference to prevention of new antibiotic resistance patterns.</p> <p><strong>Keywords</strong>: <em>E.coli</em>, Extended-spectrum beta-lactamase, PCR, Gene CTX, SHV</p> Ashrafali Rezaie Kehkhaie, Kolsoum Rezaie Kahkhaie, Leili Rezaie Kahkhaie, Maryam Koochakzai, Khadije Rezaie Keikhaie ##submission.copyrightStatement## Mon, 02 Jul 2018 12:53:33 +0430 Determining and Comparing the Level of Bilirubin in Icteric Full-term Neonates, Using Three Different Methods: Portable Jaundice Meter, Lab Data and Clinical Estimation <p><strong>Background:</strong> Neonatal jaundice is a common phenomenon. The gold standard for determining bilirubin levels is total serum bilirubin using a blood sample in a laboratory setting. Unfortunately this is an invasive and painful method which compared to portable bilirubin meter devices is associated with some delays in revealing data. Therefore a convenient and non-invasive method could be substituted.</p> <p><strong>Methods:</strong> This is a cross-sectional analytic study conducted on 52 term infants with jaundice in Shahid Sadoughi hospital during summer to winter 2015 in Yazd, Iran. At the first, the bilirubin level was estimated through clinical assessment by a nurse. Then bilirubin level in newborns was measured with Jaundice meter GM103 in the area between the eyebrows. Finally, blood samples from neonates were taken and sent to the lab. All demographic data and measured bilirubin amounts were analyzed by software SPSS v.17.</p> <p><strong>Results: </strong>The mean serum bilirubin level in newborns reported by the laboratory was 14.39 ± 5.13 however the mean for bilirubin level in newborns measured by the portable device and assessed by the nurse were 12.84 ± 3.7 and 13.5 &nbsp;±3.5 respectively. The comparison tests including Chi-square and Student T test showed a statistically significant difference between all these methods (P &lt; 0.05).</p> <p><strong>Conclusion:</strong> The data showed that regarding to a statistically significant difference between bilirubin measurement methods (P &lt; 0.05), these methods cannot be used as alternatives to each other and determining of serum bilirubin as the preferred method should always takes priority.</p> <p><strong>Keywords:</strong> Jaundice, Jaundice meter, Clinical estimation, Total serum bilirubin</p> Mohamad Hosein Lookzadeh, Samira Sadeghi, Mahmood Noori-Shadkam, Heidar Salehi, Khadijeh Nasiriani ##submission.copyrightStatement## Tue, 03 Jul 2018 09:08:52 +0430 Association of MTHFR A1298C Polymorphism with Preterm Birth: a Systematic Review and Meta-Analysis <p><strong>Background:</strong> A few studies have been conducted to explore the association of MTHFR A1298C (rs1801131) polymorphism with preterm birth risk, the results remain inconsistent. Therefore, we conducted a meta-analysis to derive a more systematic estimation of the association.</p> <p><strong>Method:</strong> Relevant studies were searched by PubMed, EMBASE, CNKI, and Google Scholar up to June 2018. The strength of the association of MTHFR A1298C polymorphism with preterm birth was calculated by odds ratios (OR) with 95% confidence interval (95%CI).</p> <p><strong>Results:</strong> A total of nine case-control studies with 1,609 cases and 14,981 controls were included. Pooled results showed that there was no significant association between MTHFR A1298C polymorphism and preterm birth risk under all five genetic models in overall. However, in the stratified analysis of ethnicity, a significant association between MTHFR A1298C polymorphism and preterm birth risk was observed in the Asians under four genetic models, i.e., allele (C vs. A: OR = 0.960, 95% CI 0.543-0.871, P = 0.002), heterozygote (CA vs. AA: OR = 0.887, 95% CI 0.024-0.457, P = 0.003), dominant (CC+CA vs. AA: OR = 0.965, 95% CI 0.534 -0.935, P = 0.015) and recessive (CC vs. CA+AA: OR = 0.923, 95% CI 0.026-0491, P = 0.004), but not in Caucasians.</p> <p><strong>Conclusion:</strong> This meta-analysis suggested that MTHFR A1298C polymorphism is not associated with preterm birth risk in overall population. However, MTHFR A1298C polymorphism plays an important role in preterm birth development in Asian population.</p> <p><strong>Keywords: </strong>Preterm Birth, MTHFR Gene, Polymorphism, Meta-analysis</p> Atiyeh Javaheri, Sahel Khajehnoori, Elnaz Foroughi, Rezvan Nasiri, Soudabeh Farahnak, Hossein Neamatzadeh ##submission.copyrightStatement## Mon, 02 Jul 2018 00:00:00 +0430 Genetic Disorders in the Fetus from Diagnosis to Treatment <p>Today there is many diseases that genetics contributes to these, including diabetes, hypertension, cancer, heart disease, various types of cancers and even mental illness, and by the advancement of medical knowledge The number of genetic diseases is increasing now. Genetic interference varies from disease to any one; in thalassemia, the genetic factor is very influential; most people think about genetic diseases as inherited diseases, while inherited diseases are part of the disease Genetic made it.</p> <p>Most of the genetic disorders currently do not have 100% treatment, and the only way is prevent them. In the field of prevention of disability and genetic disorders, many members who are at risk of genetic disease should have genetic counseling to get useful information about it. Without genetic counseling, genetic testing is meaningless, as people do not go to the laboratory without a doctor's visit; Genetic counselors do not stop people from getting married, but they provide solutions to prevent them from disorders. Having more information about the genetic disorders can change how you feel about this disease and you will be able to control genetic disorders during fetal period. This is important because unfortunately most of the genetic disorders do not have treatment throughout the lifespan of the affected person. Deafness, blindness, and mental retardation are among the most important genetic disorders. The aim of this study is to provide information on genetic diseases and prevent them in newborns and provide new solutions for the treatment of these diseases.</p> <p><strong>Keywords:</strong> Genetic, Fetus, Diagnosis</p> Tayebeh Rabaninia, Mahta Mazaheri ##submission.copyrightStatement## Tue, 03 Jul 2018 09:40:10 +0430 CRISPR Gene Editing on Human Embryos <p><strong>Background:</strong> The CRISPR/Cas system is an archaeal and bacterial adaptive immune defense system that slices foreign genetic material. Short repeats separated by genetically unique spacers are in the CRISPR locus within the prokaryotic genome. These spacers contain genetic material from invading mediators such as viruses. The CRISPR locus to enable immunity, is transcribed and processed into mature CRISPR RNA (crRNA) comprising the spacer sequence complementary to the foreign genetic material.</p> <p><strong>Methods:</strong> RISPR-Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR Associated protein 9) is demonstrating to be a well-organized and customizable alternative to other present genome editing tools. CRISPRs do not need to be paired with separate cleaving enzymes as other tools do, Since the CRISPR-Cas9 system itself is accomplished of cutting DNA strands. To lead them to their DNA targets, they can also easily be matched with tailor-made “guide” RNA (gRNA) sequences designed.</p> <p><strong>Results: </strong>Usage of CRISPR to modify human embryos public attention and anxiety over the technique.</p> <p><strong>Conclusion:</strong> Within the 'CRISPR applications on human embryos: big ado about nothing? 'Section, we introduce the applications on human embryos and the debate that has ensued internationally.</p> <p><strong>Keywords:</strong> CRISPR, Gene Editing, Human Embryos</p> Fatemeh Sefid, Saedeh Khadempar, Roshanak Shamriz, Mahta Mazaheri ##submission.copyrightStatement## Tue, 03 Jul 2018 09:45:39 +0430 A 3 Year Old Child with Farber Disease Treated with Bone Marrow Transplantation <p><strong>Background: </strong>Farber disease is a very rare autosomal recessive disease of lipid metabolism caused by deficient activity of lysosomal acid ceramidase. Symptoms can begin in the first year of life by a triad of painful and swollen joints and subcutaneous nodules, progressive hoarseness and variable central nervous system involvement.</p> <p><strong>Case Report: </strong>The patient is a 3 year old girl. In 5 months old, she with subcutaneous nodules in limbs, pain and swelling in her fingers, Knees, elbow and hoarsenessreferred to Pediatric Endocrinology Clinic of Shahid Sadoughi hospital, Yazd, Iran. She had neurodevelopment delay in walking and talking. Genetic study was reported homozygous mutation (C.830 &gt; A) in exon 11 with diagnosis of Farber disease. She treated with bone marrow transplantation. After that her signs and symptoms were improved and she could to walk.</p> <p><strong>Conclusion: </strong>Farber disease is associated with characteristics including swollen joints, subcutaneous nodules, progressive hoarseness and variable CNS involvement. Moreover, bone marrow transplantation improved these symptoms.</p> <p><strong>Keywords:</strong> Farber disease, Bone marrow Transplantation, CNS involvement</p> Naser Ali Mirhosseini, Elham Farasat, Elnaz Sheikhpour ##submission.copyrightStatement## Tue, 03 Jul 2018 09:49:43 +0430